Fig. 1: Structural overview of hHDAC8 and its catalytic process.
From: Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051
A The catalytic process of hHDAC8. B The chemical structure of SAHA. C The chemical structure of PCI-34051. D The loops and helices’ name of hHDAC8 (PDB: 3F07). L1: 30–36; L2-A: 97–107; L2-B: 84–92; L3: 136–156; L4: 176–182; L5: 202–226; L6: 263–280; L7: 301–307; L8: 341–358; α1: 21–29; α2: 37–48; α3: 64–70; α4: 73–83; α5: 108–126; α6: 157–169; α7: 183–190; α8: 237–254; α9: 281–294; α10: 308–323; α11: 358–373.
