Fig. 4: HDX difference for SAHA and PCI-34051 binding.
From: Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051
A, B HDX difference plots for the SAHA group and PCI-34051. The classification of regions is highlighted on the crystal structure (PDB code: 3F07). Pink refers to Binding regions. Purple blue refers to distant conformational change regions. Yellow refers to L2-A. C, D The representative peptides show significant HDX changes of SAHA and PCI-34051.
