Fig. 3: Macrophage depletion attenuates CaOx crystal-induced kidney fibrosis. | Communications Biology

Fig. 3: Macrophage depletion attenuates CaOx crystal-induced kidney fibrosis.

From: EZH2-mediated macrophage-to-myofibroblast transition contributes to calcium oxalate crystal-induced kidney fibrosis

Fig. 3

A Renal function and body weight were measured on day 12 of modeling (n = 6). B Schematic diagram of the experimental procedure, Created in BioRender. Yuqi, X. (2025) https://BioRender.com/d40q387. C Representative pictures of HE, Masson, and immunohistochemical staining (magnification, ×400). D Quantifying hydroxyproline content, F4/80+ cells, collagen deposition area and α-SMA positive area (n = 6). Data are presented as the mean ± SEM. *p < 0.05 versus control group; #p < 0.05 versus CaOx nephrocalcinosis group. P values were determined by the two-tailed Student’s t test.

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