Fig. 5: Ezh2 deletion decreases MMT cells and attenuates CaOx crystal-induced kidney fibrosis. | Communications Biology

Fig. 5: Ezh2 deletion decreases MMT cells and attenuates CaOx crystal-induced kidney fibrosis.

From: EZH2-mediated macrophage-to-myofibroblast transition contributes to calcium oxalate crystal-induced kidney fibrosis

Fig. 5

A Renal function and body weight were measured on day 12 of modeling (n = 6). Representative pictures of HE staining, Sirus rad staining (B), Von Kossal staining (C), α-SMA and Collagen I immunohistochemistry staining (D) (n = 6). E Two-color immunofluorescence identifies MMT cells (n = 6). F EZH2, Collagen I, α-SMA and fibronectin were expressed by immunoblotting in nephrocalcinosis mice (n = 3). Data are presented as the mean ± SEM. *p < 0.05 versus Ezh2fl/fl group; #p < 0.05 versus CaOx Ezh2fl/fl group. P values were determined by the two-tailed Student’s t test.

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