Fig. 5: ELF-1 deficiency enhanced expression of chemokines in colonic epithelial cells in DSS-induced colitis.
From: Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis
A UMAP plots and proportions of the identified subtypes in colonic epithelial cells from the colonic tissues of DSS-treated WT and Elf-1−/− mice. B Tracksplot of top 3 marker genes for the subpopulations of colonic epithelial cells as indicated. C Ligand‒receptor interaction between colonic epithelial cell and immune cell types. D KEGG analysis of up-regulated DEGs in colonic epithelial cells of DSS-treated Elf-1−/− mice. E Expressions of representative genes of cytokine-cytokine receptor interaction signaling pathways in colonic epithelial cells of DSS-treated WT and Elf-1−/− mice. F The mRNA levels of Cxcl13, Cxcl2, Cxcl1, Ccl2, Ccl11, Ccl3 and Il1b in colonic epithelial tissues of normal and DSS-treated WT and Elf-1−/− mice (n = 4). Data are shown as mean ± SD, representing one of at least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.
