Fig. 3: Interactions between the genes EIF3B, RUVBL1, RPS13, RPL7, RPL23, TSR1 as predicted by Mean Difference (top 5k) and Guanlab (top 1K) on RPE1.
From: A large-scale benchmark for network inference from single-cell perturbation data
Green interactions are predicted by both methods, blue by Mean Difference (top 5k) and red by Guanlab (top 1k). Mean Difference (top 5k), which has a lower FOR, recalls more interactions in this complex. However, it also predicts interactions with RUVBL1 that are more uncertain, and that are more likely indirect rather than direct. Guanlab (top 1k), which has a higher mean Wasserstein, recovers fewer interactions, but all of its predicted interactions among ribosomal proteins and TSR1, which are essential for ribosomal assembly and function, are highly likely. However, it omits the interactions with EIF3B, a key component of the translation initiation factor complex.
