Fig. 3: Abnormal B cell metabolism in membranous nephropathy.
From: Impact of immune cell metabolism on membranous nephropathy and prospective therapy
Rapamycin complex (mTORC)-mediated glycolytic targets are enhanced by activation in MN B cells, leading to primitive B cell expansion. Glutaminolysis has also been found to contribute to primitive B differentiation in MN. Fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) in MN B cells, leading to expansion of plasma cells (PCs). BCR B-cell receptor. This image was created by Figdraw.
