Fig. 4: The Developmental Differentiation and Metabolism of T Cells.
From: Impact of immune cell metabolism on membranous nephropathy and prospective therapy
Naïve T cells are sustained in a dormant state by low levels of OXPHOS. Upon encountering an antigen, T cells experience significant metabolic reprogramming, altering their reliance on glycolysis to facilitate their activation and differentiation into effector T-cell. Conversely, memory T cells and regulatory T cells (Treg) rely on OXPHOS and FAO to support their survival and differentiation. TCR T cell receptor, ETC electron transport chain, IDO indoleamine 2,3-dioxygenase, mTOR mammalian target of rapamycin, FAS fatty acid synthesis, ACC1 acetyl-CoA carboxylase 1, TCA tricarboxylic acid cycle. This image was created by Figdraw.
