Fig. 4: Box plots of the FC Network in ICA-AROMA+2Phys + GSR.

For each FC between two networks in Yeo’s 17-Network parcellation, the box plot shows the distribution and significance of FC between two groups among the four denoising strategies (A: HMP+2Phys, uncorrected; B: HMP+2Phys+GSR, uncorrected; C: ICA-AROMA+2Phys, uncorrected; D: ICA-AROMA+2Phys+GSR, uncorrected; E: ICA-AROMA+2Phys+GSR, FDR corrected). In each grid, the left box represents the results of the TD group, and the right box represents the results of the ASD group. When the two groups show a significant difference, the block shows a yellow background and star symbol (*denotes p < 0.05, **denotes p < 0.01, ***denotes p < 0.001). X-axis and y-axis labels denote the network number in Yeo’s 17-Network parcellation. For network 6 which mainly represent the postcentral frontal, the significantly different regions (p < 0.01) between two groups across four strategies ranged from None, 11, 4-14, and 4-11 networks, as denoted by the red boxes. For network 11 which mainly represent the PCC, the significantly different regions (p < 0.01) between the two groups in the four strategies were ranged from None, 6-7-8, 8-12, and 6-7-8-12-16-17 networks, as denoted by green boxes. After applying FDR correction, significant results were observed only under ICA-AROMA+2Phys+GSR strategy, as shown in Fig. 4E.