Table 3 DNAm age differences between EPICv1 and EPICv2 in buffy coat, PBMC, and saliva assessed using Wilcoxon Signed-Rank test
DNAm clocks | Biological samples | Median difference [IQR] | p-value |
|---|---|---|---|
PCHorvath1 | PBMC | 1.05 [0.629; 1.57] | 0.000305** |
Buffy coat | 1.24 [0.877; 1.47] | 0.0000305*** | |
Saliva | 4.23 [2.94; 5.36] | 0.000061*** | |
PCHorvath2 | PBMC | 1.4 [1.16; 1.62] | 0.000061*** |
Buffy coat | 0.572 [0.279; 0.933] | 0.0000916** | |
Saliva | 1.56 [1.07; 5.26] | 0.0000916** | |
PCHannum | PBMC | 0.493 [0.176; 0.93] | 0.029 |
Buffy coat | 0.423 [-0.141; 0.677] | 0.175 | |
Saliva | 0.306 [-0.0598; 2.97] | 0.0654 | |
PCPhenoAge | PBMC | -0.761 [-1.38; -0.376] | 0.00214* |
Buffy coat | -2.17 [-2.38; -1.5] | 0.000061*** | |
Saliva | -1.65 [-2.49; -0.45] | 0.000427** | |
PCGrimAge | PBMC | -0.489 [-0.599; -0.16] | 0.0335 |
Buffy coat | -0.71 [-0.943; -0.396] | 0.000214** | |
Saliva | -1.02 [-1.23; -0.23] | 0.00629 | |
PCDNAmTL | PBMC | 0.0079 [0.00231; 0.02] | 0.00763 |
Buffy coat | 0.00135 [-0.00358; 0.0108] | 0.597 | |
Saliva | -0.00457 [-0.0111; 0.0112] | 0.782 | |
DNAmFitAge | PBMC | -1.9 [-4.27; -0.957] | 0.00101* |
Buffy coat | -4.12 [-6.25; -2.65] | 0.000153** | |
Saliva | -4.13 [-6.37; -0.939] | 0.000763** | |
DunedinPACE | PBMC | 0.104 [0.0738; 0.159] | 0.00336* |
Buffy coat | 0.103 [0.0409; 0.119] | 0.0000916** | |
Saliva | 0.0653 [-0.00428; 0.105] | 0.0443 | |
YingAdaptAge | PBMC | 2.08 [-0.56; 4.89] | 0.144 |
Buffy coat | -4.56 [-7.72; -1.86] | 0.0000916** | |
Saliva | -3.65 [-7.81; 0.0805] | 0.011 | |
YingDamAge | PBMC | -6.51 [-9.02; -4.57] | 0.000153** |
Buffy coat | -6.95 [-8.11; -3.43] | 0.00101* | |
Saliva | -5.69 [-11.2; 0.138] | 0.159 | |
YingCausAge | PBMC | -8.43 [-10.1; -6.37] | 0.0000305*** |
Buffy coat | -6.28 [-7.52; -4.51] | 0.00058** | |
Saliva | -3.46 [-7.59; 0.498] | 0.0386 |
