Table 1 The mendelian analysis and colonization analysis of causalities between breast cancer and plasma proteins

From: Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates

Gene

Outcome

Method

nsnp

FDR

PH4

Tier

OR

95% CI

KPNA2

Breast cancer

Wald ratio

1

0.023

0.545

2

0.634

(0.489,0.822)

CSK

Breast cancer

Wald ratio

1

0.001

0.849

1

0.639

(0.527,0.775)

DNAJC27

Breast cancer

Wald ratio

1

0.097

0.0002

3

0.659

(0.493,0.883)

ACADVL

Breast cancer

Wald ratio

1

0.04

0.204

3

0.663

(0.516,0.853)

FAM49B

Breast cancer

Wald ratio

1

0.033

0.039

3

0.669

(0.526,0.85)

ULK3

Breast cancer

Wald ratio

1

0.0001

0.964

1

0.68

(0.586,0.79)

CP

Breast cancer

Wald ratio

1

0.097

0.12

3

0.709

(0.556,0.903)

CDKN1B

Breast cancer

Wald ratio

1

0.08

0.282

3

0.792

(0.678,0.925)

OMG

Breast cancer

Wald ratio

1

0.066

0.0002

3

0.795

(0.685,0.923)

SNUPN

Breast cancer

IVW

2

0.001

0.722

2

0.802

(0.732,0.878)

TNFRSF19

Breast cancer

IVW

2

0.079

0.077

3

0.832

(0.746,0.928)

UBE2C

Breast cancer

Wald ratio

1

0.087

0.053

3

0.88

(0.807,0.961)

RSPO3#

Breast cancer

IVW

6

0.061

0.583

2

0.895

(0.84,0.953)

RSPO3*

Breast cancer

IVW

6

0.061

0.631

2

0.905

(0.854,0.958)

GSTT2B

Breast cancer

IVW

13

0.023

0.257

3

0.928

(0.893,0.964)

FLRT3

Breast cancer

IVW

26

0.047

0.124

3

0.969

(0.953,0.986)

SWAP70

Breast cancer

IVW

14

0.074

0.644

2

1.074

(1.03,1.12)

CCBL2

Breast cancer

IVW

10

0.009

0.473

3

1.088

(1.045,1.133)

ASIP

Breast cancer

IVW

6

0.009

0.896

1

1.097

(1.049,1.148)

PEAR1

Breast cancer

IVW

8

0.002

0.01

3

1.115

(1.064,1.169)

ADH5

Breast cancer

IVW

5

0.061

0.549

2

1.128

(1.053,1.21)

RALB

Breast cancer

IVW

2

0.001

<0.0001

3

1.142

(1.085,1.202)

CNPY3

Breast cancer

Wald ratio

1

0.087

0.029

3

1.153

(1.046,1.272)

COL6A3

Breast cancer

IVW

2

0.046

0.794

2

1.200

(1.086,1.326)

SARS2

Breast cancer

Wald ratio

1

0.033

0.523

2

1.209

(1.08,1.353)

CETN3

Breast cancer

Wald ratio

1

0.089

<0.0001

3

1.281

(1.08,1.519)

NPPA

Breast cancer

Wald ratio

1

0.085

0.29

3

1.339

(1.1,1.63)

TLR1

Breast cancer

IVW

2

0.009

0.987

1

1.375

(1.179,1.604)

SERPIND1

Breast cancer

Wald ratio

1

0.029

0.034

3

1.576

(1.208,2.056)

LAYN

Breast cancer

Wald ratio

1

0.002

0.609

2

1.65

(1.312,2.076)

TFPI2

Breast cancer

Wald ratio

1

0.051

<0.0001

3

1.657

(1.206,2.278)

PELO

Breast cancer

Wald ratio

1

0.005

0.064

3

1.712

(1.308,2.241)

DOK2

Breast cancer

Wald ratio

1

0.085

0.028

3

1.722

(1.192,2.486)

UBE2N

Luminal_A

Wald ratio

1

0.005

0.934

1

0.499

(0.356,0.698)

CSK

Luminal_A

Wald ratio

1

<0.0001

0.728

2

0.509

(0.395,0.657)

KPNA2

Luminal_A

Wald ratio

1

0.096

0.096

3

0.575

(0.408,0.811)

ULK3

Luminal_A

Wald ratio

1

<0.0001

0.806

1

0.597

(0.489,0.727)

SYT11

Luminal_A

Wald ratio

1

0.03

<0.0001

3

0.64

(0.499,0.821)

SNUPN

Luminal_A

IVW

2

<0.0001

0.669

2

0.721

(0.639,0.813)

OMG

Luminal_A

Wald ratio

1

0.098

0.091

3

0.735

(0.604,0.894)

SRA1

Luminal_A

IVW

3

0.06

0.295

3

0.804

(0.715,0.903)

FBLN1

Luminal_A

IVW

5

0.073

0.032

3

0.862

(0.79,0.941)

NID1

Luminal_A

IVW

9

0.09

0.072

3

0.882

(0.817,0.952)

EPHB1

Luminal_A

IVW

15

0.073

0.298

3

0.93

(0.891,0.971)

SERPING1

Luminal_A

IVW

20

0.044

0.111

3

0.943

(0.915,0.972)

FGF2

Luminal_A

IVW

23

0.073

0.386

3

0.95

(0.923,0.978)

LCT

Luminal_A

IVW

13

0.073

0.021

3

1.044

(1.019,1.07)

IDUA

Luminal_A

IVW

26

0.073

0.029

3

1.048

(1.021,1.077)

CYB5R2

Luminal_A

IVW

16

0.073

0.017

3

1.082

(1.035,1.131)

CCBL2

Luminal_A

IVW

9

0.073

0.091

3

1.098

(1.041,1.159)

SWAP70

Luminal_A

IVW

14

0.073

0.235

3

1.099

(1.04,1.162)

RALB

Luminal_A

IVW

2

0.073

<0.0001

3

1.123

(1.049,1.201)

ANXA4

Luminal_A

IVW

8

0.09

0.023

3

1.136

(1.051,1.228)

ADH5

Luminal_A

IVW

5

0.073

0.863

1

1.200

(1.079,1.335)

CTSF

Luminal_A

IVW

3

0.005

<0.0001

3

1.214

(1.113,1.325)

SARS2

Luminal_A

Wald ratio

1

0.015

0.876

1

1.323

(1.142,1.532)

LAYN

Luminal_A

Wald ratio

1

0.005

0.707

2

1.866

(1.379,2.524)

UBASH3B

Luminal_B

IVW

2

0.027

0.754

2

0.596

(0.465,0.762)

CDH17

Luminal_B

IVW

15

0.027

0.314

3

1.172

(1.086,1.264)

PEX14

Luminal_B

Wald ratio

1

0.028

0.873

1

3.268

(1.834,5.822)

KLRB1

Triple_Negative

IVW

2

0.047

0.014

3

0.316

(0.176,0.566)

IL1RL1

Triple_Negative

IVW

34

0.042

0.3

3

0.92

(0.883,0.958)

  1. * & # stand different probes in the Decode database: *13094_75 #8427_118;
  2. FDR false discovery rate, PH4 posterior probability of H4, Nsnp number of single nucleotide polymorphisms, IVW inverse-variance weighted, OR odds ratio, 95% CI 95% confidential interval.
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