Fig. 6: Impaired type-I interferon response genes (ISGs) expression in T cells, monocytes and B cells of severely and critically ill COVID-19 patients.
From: CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responses
Dot plot depicting expression levels of ISGs in the: A T cell subpopulation, B monocyte subpopulation, and C B cell subpopulation, across disease state. The dot size represents the fraction of cells in the clusters, mean expression is colour coded as indicated. D ISG score changes in COVID-19 patients of different disease severity and healthy controls in the T cell subpopulation, E monocyte subpopulation and F the B cell subpopulation. Mean expression box plots, with error bars representing the 95% bootstrapped confidence intervals around the mean. Statistical analysis performed by the Mann–Whitney–Wilcoxon test two sided with Bonferroni correction ****p < 0.0001.
