Fig. 6: FGF and BMP dependent changes in H3K27me3 enrichment on limb patterning gene regions. | Communications Biology

Fig. 6: FGF and BMP dependent changes in H3K27me3 enrichment on limb patterning gene regions.

From: Neural regulation of H3K27me3 during the induction of patterning competency in regenerating Axolotl limb cells

Fig. 6

a Simplified gene maps of genes associated with A/P, D/V, and Pr/Di limb patterning where the general locations of regions with significant nerve-dependent changes in H3K27me3 enrichment are compared to lateral wounds are indicated with rectangles. Green boxes indicate regions that flipped enrichment trend in FGFi (LND193189) treated ND-As compared to DMSO treated. Pink boxes indicate regions that flipped enrichment trend in BMPi (SU5402) treated ND-As compared to DMSO treated. Yellow boxes indicate regions that either had additive or co-dependent changes in inhibitor treated samples. Orange boxes indicate regions that exhibited changes in enrichment in the inhibitor groups that do not fit with the above definitions. Gray boxes indicate changes in enrichment that occur independently of FGF and BMP signaling. Numbered white rectangles indicate promoters (P) and exons (1-1+n). b Heat maps of log2FC values for regions in which differential H3K27me3 abundance were detected in limb patterning genes associated with Anterior-Posterior, Dorsal-Ventral, and Proximal-Distal limb patterning in ND-A samples compared to lateral wounds. Regions are displayed in 5’ to 3’ order. Complete data used to generate a and (b) provided in Supplementary Data 6.

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