Fig. 3: Changes in the phosphoproteome of the male mouse heart.

a Bars represent the number of phosphosites detected in each genotype (n = 5 wild-type, n = 4 NOS1, n = 5 NOS2, n = 5 NOS3, n = 4 sGCα1, and n = 5 tNOS null mice). The number of significantly different from wild-type (adjusted p-value < 0.05) regulated sites is indicated in red and in parentheses. b Gene ontology enrichment analysis of the 161 phosphoproteins with 401 regulated phosphosites in the tNOS null mice. The data depicts four major enriched biological processes. The size of the circles indicates the number of proteins in the cluster, and the color bar signifies the fold change from the wild-type mice.