Fig. 4: Analysis of the cysteine S-nitrosylation proteome.
a The bars indicate the number of precisely identified S-nitrosocysteine sites (red) and the corresponding proteins (blue) for each genotype (n = 6 wild-type, n = 6 NOS1, n = 6 NOS2, n = 6 NOS3, null mice). Insert indicates the relative abundance levels of the NOS isoforms in the mouse heart. b Gene Ontology analysis for biological processes enriched in the 336 proteins that are S-nitrosylated in wild-type but not in NOS3 mouse hearts. The X-axis indicates the combined score, the natural log of the p-value multiplied by the z-score, where the z-score is the deviation from the expected rank from the Enrichr95 analysis. c The same as b for the cellular component, indicating the localization of the proteins.
