Fig. 5: Pathway-specific analysis in the tNOS null mice. | Communications Biology

Fig. 5: Pathway-specific analysis in the tNOS null mice.

From: Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies

Fig. 5

a Manually curated sub-proteomes for major functional pathways were used to identify proteins, and phosphoproteins detected and/or regulated in the tNOS null mice. The number of regulated proteins includes S-nitrosylated proteins in the wild-type hearts, which are missing in the tNOS null mice. b Graphical depiction of the canonical signaling cascade of NO/cGMP that includes downstream targets of Prkg1 phosphorylation and a heat map depicting changes in the proteome and phosphoproteome in this pathway for all genotypes. c Heat map depicting changes in the proteome and phosphoproteome for the cardiomyocyte contraction pathway. White boxes indicate that the protein or the phosphoprotein was not detected.

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