Fig. 6: Regulated kinases and phosphatases in the tNOS mice hearts. | Communications Biology

Fig. 6: Regulated kinases and phosphatases in the tNOS mice hearts.

From: Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies

Fig. 6

a We generated reference lists of 295 and 116 putative kinases expressed in mouse hearts by curating data from available resources. In the proteome, phosphoproteome, and S-nitrosocysteine proteome, we assess changes in 49% of the putative kinases and 35% of the phosphatases expressed in the heart. b Kinases that were significantly regulated (adjusted p-value < 0.05) at the proteome level. c Fold changes in the relative abundance of phosphosites in kinases. Phosphosites Slk_T1931, Speg_S1954, and Speg_T1956 were below the detection level in tNOS null mice. The relative levels of Stk, Camk2d, and Akt1 were also regulated at the protein level.

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