Fig. 2: RBAP48 promotes AR-mediated transactivation. | Communications Biology

Fig. 2: RBAP48 promotes AR-mediated transactivation.

From: RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners

Fig. 2

A Luciferase assays indicated that RBAP48 up-regulated AR-mediated gene transcription in HEK-293 cells with DHT. Student t-tests were used, and p < 1e-2**. B Multiple luciferase assays showed RBAP48 increased the AR full-length and AR-AF2 domain transactivation. C-D Relative luciferase assays indicated the function of RBAP48 on AR-mediated transactivation in CAL-27 cells and SCC-9 cells. E RNA-seq heatmap showed that RBAP48 significantly affected genes in the absence and presence of DHT (p < 5e-2*, FC > 2), and gene clusters were divided into four groups according to expression levels. F The Venn diagram showed the number of genes up-regulated and down-regulated by RBAP48 in DHT-untreated and DHT-treated conditions.

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