Fig. 5: RBAP48 affects the recruitment of WRAD subcomplexes to gene promoter regions. | Communications Biology

Fig. 5: RBAP48 affects the recruitment of WRAD subcomplexes to gene promoter regions.

From: RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners

Fig. 5

A-B (A) Go-TRRUST and (B) Go-Transcription Factor Targets detection revealed the Transcription factors enriched by the above significantly changed genes and the downstream of the potential Transcription factors enriched without DHT treated, respectively. C-D STRING analysis revealed the potential protein interaction network of RBAP48 when interacting with (C) AR or (D) SP1, respectively. E co-IP assays indicated the endogenous interaction between RBAP48 and AR with DHT treated in CAL-27 cells. F In CAL-27 cells, co-IP assays with the RBAP48 knockdown represented the AR and WRAD subcomplex interaction changes. G The impact of ASH2L depletion on the interplay between RBAP38 and AR protein in CAL-27 cells. H RBAP48 reduction on the interaction among the transcription factors SP1/RELA with RBAP48 in CAL-27 cells.

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