Fig. 7: RBAP48 promotes OSCC cell growth and resistance to external stimulation. | Communications Biology

Fig. 7: RBAP48 promotes OSCC cell growth and resistance to external stimulation.

From: RBAP48 facilitates the oral squamous cell carcinoma process in an androgen receptor-dependent and independent manners

Fig. 7

A-B Typical illustration of ectopic tumorigenesis in mice and tumor size. Tumor cells were completed by stably silencing RBAP48 CAL-27 cells with lentivirus. C-D Comparison of tumor-bearing volume and final tumor-bearing weight in mice. The student t-tests were used between two groups. E The mRNA expression of RBAP48 and its regulated genes were detected by qPCR assay using RNA extracted from tumor tissue as template. F Cell clone formation assay showed the effect of RBAP48 silencing on cell colony size and number. G-H Cell growth curve experiments showed the effects of RBAP48 silencing on cell growth under DHT treatment and DHT treatment, respectively. I Cell growth curve assay showed that overexpression of RBAP48 reversed the growth inhibition effect of CDK4/6 inhibitor. J Schematic representation of the key role of RBAP48 different transcription patterns jointly promote the biological function of OSCC cells biological function such as stimulation response and cell growth in the absence of DHT treatment and DHT treatment.

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