Fig. 3: Heat shock challenge elicits a classical heat shock signature in mice but not bats.
From: Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus
A Global differentially up- and down- regulated DEG ( >2 FC and 0.05 < FDR) of HS and HS + R conditions when compared against Ctl group in mice (Mm) (B) and bats (Es) (Supplementary Data 1). C Bar graph comparing the number of DEG found in mice (Mm) and bats (Es) upon different conditions, the number indicates the total DEG involved in all organs. Comparisons made were against Ctl group. D Venn diagram of overlapping DEG found across organ in mice (Mm) (E) and bats (Es) acutely in HS condition. F Intersecting upregulated DEG of all mice (Mm) HS organs and filtering genes belonging to inducible HSP family genes and co-chaperones. G Filtered GSEA against GOBP pathways comparing chaperone mediated protein folding between mice (Mm) and bats (Es) of different condition and organs (Supplementary Data 3). H Transcription factor enrichment analysis of DEG set list defined in (A) for HS timepoint in mice (Mm) organs, analysis was done using ChEA3 against ENCODE database (Supplementary Data 5). Figures were created with elements from BioRender (2025). https://BioRender.com/0fcvmt1.
