Fig. 10: Non-genomic signaling in adult retinas is altered after developmental BPA exposure. | Communications Biology

Fig. 10: Non-genomic signaling in adult retinas is altered after developmental BPA exposure.

From: Loss of adult visual responses by developmental BPA exposure is correlated with altered estrogenic signaling

Fig. 10

Western Blot and quantification for MAPK protein and AKT phosphorylation in retinal homogenates of adult fish exposed to water, vehicle (0.0003% DMSO), low BPA (0.001 µM), or high BPA (0.1 µM) when they were 72 hpf (left) (A–D) or 7 dpf (right) (E–H). A, E ERK, p-ERK. B, F JNK, p-JNK. C, G P38, p-P38. D, H AKT, p-AKT. N = 2 fish per treatment for each blot. For all blots, β-actin was used as a loading control. Quantification was performed using values obtained from densitometry analysis and normalizing phosphorylated protein to total protein and water control. Box plots show fold change. Asterisks indicate statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001.

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