Fig. 5: Low BPA exposure at 72 hpf affected adult photopic ERG responses. | Communications Biology

Fig. 5: Low BPA exposure at 72 hpf affected adult photopic ERG responses.

From: Loss of adult visual responses by developmental BPA exposure is correlated with altered estrogenic signaling

Fig. 5

A–F Mean photopic ERG recordings (top) from retinal eyecup preparations from adults exposed to water, vehicle (0.0003% DMSO), low BPA (0.001 µM), or high BPA (0.1 µM) when they were 72 hpf. Traces shown represent the mean response to the brightest stimulus (3.0 ND) from all eye cups in a given treatment group. Water = 5 eyes; vehicle = 10 eyes; low BPA = 6 eyes; high BPA = 18 eyes. The tissue was stimulated by 300 msec full-field white light pulses at 7 irradiance levels ranging from ND 3.0 (brightest)–6.0 (dimmest) in 0.5 increments. Red square pulse on all graces represents the photocell. White-light ERG responses had clear a-wave, b-wave, and d-wave components (noted on vehicle trace at top), which were evoked on an infrared (IR, RG780 filter) background. A a-wave amplitude, B a-wave trough time, C b-wave amplitude, D time to b-wave peak, E d-wave amplitude, F d-wave peak time. Data in A–F are presented as box and whisker plots: median line is in the center of the box and the ‘x’ is the mean. Significant differences are indicated with asterisks (α = 0.05).

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