Fig. 6: High BPA exposure at 7 dpf affects ERG a-wave and d-wave responses. | Communications Biology

Fig. 6: High BPA exposure at 7 dpf affects ERG a-wave and d-wave responses.

From: Loss of adult visual responses by developmental BPA exposure is correlated with altered estrogenic signaling

Fig. 6

A–F Mean ERG recordings (top) from retinal eyecup preparations from adults exposed to water, vehicle (0.0003% DMSO), low BPA (0.001 µM), or high BPA (0.1 µM) when they were 7 dpf. The tissue was stimulated by 300 msec full-field white light pulses at 7 irradiance levels ranging from ND 3.0 (brightest)–6.0 (dimmest) in 0.5 increments. These ERGs were in response to 10 replicates of a 7-step irradiance response series covering a 3-log unit range. Traces shown represent the mean response to the brightest stimulus (3.0 ND) from all eye cups in a given treatment group. Water = 11 eyes; Vehicle = 6 eyes; low BPA = 13 eyes; high BPA = 5 eyes. ERG a-wave, b-wave, and d-wave components are noted on the vehicle trace at the top. A a-wave amplitude. B a-wave trough time. C b-wave amplitude. D time to b-wave peak. E d-wave amplitude. F d-wave peak time. Data in A–F are presented as box and whisker plots: median line is in the center of the box and the ‘x’ is the mean. Significant differences are indicated with asterisks (α = 0.05).

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