Fig. 1: Bioinformatics analysis revealed that NHE7 expression in EC correlates with poor prognosis and senescence. | Communications Biology

Fig. 1: Bioinformatics analysis revealed that NHE7 expression in EC correlates with poor prognosis and senescence.

From: NHE7 drives endometrial cancer progression by delaying senescence through cAMP/CREB/GRIN2B axis-mediated Ca²⁺ influx

Fig. 1

Transcriptome sequencing analysis was performed to identify DEGs in EC and normal samples from TCGA database. A The DEGs between EC and normal samples were analyzed, and their distribution was depicted using a volcano plot (the genes related to senescence have been marked on the diagram). The biological processes and signaling pathways in which DEGs were enriched were identified by B KEGG and C GO enrichment analysis. D The overlap of EC DEGs with senescence-related genes from the literature was visualized with a Venn diagram. E The intersection genes were analyzed using univariate Cox analysis (p < 0.001). F The box plots were used to illustrate the expression levels of NHE7 in EA and SC tumor tissues or healthy tissues. G Survival curve analysis was used to assess the prognostic effect of high or low NHE7 expression in tumor patients.

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