Fig. 4: The PAG may be involved in constructing social memory between mouse groups. | Communications Biology

Fig. 4: The PAG may be involved in constructing social memory between mouse groups.

From: Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity

Fig. 4

A Experimental timeline for c-Fos immunohistochemistry: Subject mice underwent 10-min social interaction followed by a 1.5-hour post-interaction interval before brain extraction. B Basal c-Fos expression in the vlPAG of untreated control mice (Ctl). Representative micrograph showing constitutive neuronal activation patterns (scale bar = 200 μm; inset: 20 μm). C Schematic of c-Fos expression in the vlPAG after mice interact with mice of same-strain mice. D Schematic of c-Fos expression in the vlPAG after mice interact with mice of other-strain mice. E Statistical graph of the number of c-Fos positive neurons in the vlPAG after mice interact with same or other strain mice. The number of c-Fos positive neurons in the vlPAG of C57 mice after interacting with same stain mice is significantly higher than after interacting with other-strain mice (Ctl: n = 4, SS/OS: n = 6). Data displayed as mean±S.E.M. *P < 0.05, ***P < 0.001.

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