Fig. 8: Overexpression of wild-type OPTN rescued RGC loss but not astrogliosis in the viscobead injection model of ocular hypertension.
From: OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies
a Schematic illustration of the OPTN overexpression in the high IOP model. Created with BioRender.com and used with permission. b Representative IF images showing wild-type OPTN overexpression alleviates high IOP-induced RGC loss but not astrogliosis. Scale bar, 50 μm. c Quantification of RGC survival in high IOP model after OPTN overexpression. d Quantification of astrogliosis in high IOP model after OPTN overexpression. Data are shown as mean ± s.e.m. with n = 5 biologically independent samples. *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant. Statistical significance among multiple groups was determined using one-way ANOVA followed by Tukey’s multiple comparisons test.
