Fig. 6: KMT2D connects glutamatergic and GABAergic synaptic signaling pathways with ASD.
From: Deficiency of KMT2D causes autistic-like behavior in mice and zebrafish
A Venn-diagram showing the overlap genes between four different gene sets: DEGs: the differentially expressed genes detected in Kmt2d-KD mice RNA-seq. Glutamatergic genes: the DEGs associated with glutamatergic synaptic response. GABAergic genes: the DEGs associated with GABAergic synaptic response. ASD genes: the genes related with ASD based on SFARI. B The ratio of DEGs associated with ASD, glutamatergic and GABAergic synaptic signaling pathway. C Conduct visualization of DEGs related to the glutamatergic and GABAergic signaling pathways using the cluGO software. D The network representing protein interaction relationship between DEGs in ASD, glutamatergic and GABAergic signaling pathways based on Kmt2d-KD mice RNA-seq.
