Fig. 4: Generalizability of OncoMark across diverse biological contexts. | Communications Biology

Fig. 4: Generalizability of OncoMark across diverse biological contexts.

From: OncoMark: a high-throughput neural multi-task learning framework for comprehensive cancer hallmark quantification

Fig. 4

a The left panel displays probability density distributions of hallmark predictions in normal tissue datasets (GTEx and ENCODE), revealing hallmark-specific variation in healthy tissues. The right panel contrasts this with hallmark activity in cancer datasets (TCGA, CCLE, POG570, PCAWG, TARGET, and MET500), showing pronounced shifts in predicted probabilities consistent with malignant transformation. b Density plot for the activating invasion and metastasis hallmark across primary tumor sites with known metastatic cases.

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