Fig. 5: OncoMark reveals associations between hallmark activity and clinical cancer staging.

Heatmaps display associations between hallmark activity and key clinical staging metrics such as (a) AJCC stage, b metastasis stage, c lymph node involvement, and d tumor size. Color intensity reflects the strength of association, with darker hues indicating stronger relationships. Asterisks (*) denote statistically significant associations (p < 0.05).