Table 2 Summary of FDR-significant (FDR < 0.1) cis-pQTLs identified in DAISY
SRM no. significant cis-pQTLs | Exsera no. significant cis-pQTLs | |||||||
|---|---|---|---|---|---|---|---|---|
Pathway(s) | Protein | Chr | Pooled | Case-stratified | Total | Pooled | Case-stratified | Total |
Lectin | MBL2 | 10 | 0 | 0 | 0 | 14 | 4 | 14 |
Classical | C1QC | 1 | 0 | 0 | 0 | 3 | 2 | 5 |
C1R | 12 | 0 | 0 | 0 | -- | -- | -- | |
C1S | 12 | 0 | 0 | 0 | -- | -- | -- | |
Classical and Lectin | C2 | 6 | 0 | 0 | 0 | 0 | 5 | 5 |
C4 | 6 | -- | -- | -- | 0 | 0 | 0 | |
C4A | 6 | 17 | 0 | 17 | -- | -- | -- | |
C4B | 6 | 9 | 0 | 9 | 0 | 1 | 1 | |
Alternative | CFB | 6 | 26 | 0 | 26 | 0 | 0 | 0 |
CFD | 19 | -- | -- | -- | 0 | 0 | 0 | |
CFP | X | 0 | 0 | 0 | 0 | 0 | 0 | |
Terminal | C5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
C5A | 9 | -- | -- | -- | 5 | 3 | 5 | |
Terminal (MAC) | C5B | 9 | -- | -- | -- | 0 | 3 | 3 |
C6 | 5 | 3 | 0 | 3 | -- | -- | -- | |
C7 | 5 | 0 | 0 | 0 | -- | -- | -- | |
C8A | 1 | 29 | 0 | 29 | -- | -- | -- | |
C8B | 1 | 2 | 0 | 2 | -- | -- | -- | |
C8G | 9 | 0 | 0 | 0 | -- | -- | -- | |
C9 | 5 | 0 | 0 | 0 | -- | -- | -- | |
Alternative and terminal | C3 | 19 | 0 | 0 | 0 | 0 | 0 | 0 |
C3A | 19 | -- | -- | -- | 0 | 0 | 0 | |
C3B | 19 | -- | -- | -- | 0 | 1 | 1 | |
CFH | 1 | 50 | 0 | 50 | 69 | 0 | 69 | |
CFI | 4 | 0 | 0 | 0 | 0 | 3 | 3 | |
