Fig. 3: The GABAergic synapse and the basement membrane are altered during bloom season.
From: Alzheimer’s disease signatures in the brain transcriptome of estuarine dolphins
a Gene Ontology (GO) enrichment analysis of molecular, cellular, and biological functions for upregulated (green; n = 420) and downregulated (orange; n = 116) dolphin genes using a human (Homo sapiens) database search. Glutamate decarboxylase activity (>100-Fold; GO:0004351) and laminin-3 complex (48.7-fold GO:0005608) were the top enriched GO terms (labeled with star). b Comparative protein-protein interaction networks of GO terms, GO:0004351 and GO:0005608, for IRL dolphins and Alzheimer’s disease (AD) patients. Relative gene expression from the frontal pole of AD versus normal controls was obtained from the Alzheimer DataLens bulk transcriptomic database. Differential expression of bloom vs non-bloom (NB) season dolphins is depicted. c Reactome pathway enrichment for GO:0004351 and GO:0005608 for dolphin (Tursiops truncatus). d Heatmap and cluster analysis of dolphin genes related to the GABAergic synapse. b was created in BioRender. Davis, D. (2025) https://BioRender.com/ovsibtb. c was generated with STRING.
