Fig. 2: ALOX5 was increased in renal tubular cells in a patient with acute tubular necrosis. | Communications Biology

Fig. 2: ALOX5 was increased in renal tubular cells in a patient with acute tubular necrosis.

From: Targeting ALOX5 ameliorates renal tubular injury in ischemia–reperfusion-induced acute kidney injury via inhibition of ferroptosis

Fig. 2

A The schematic graph showing the experimental process. B The pathological examinations of adjacent non-tumorous kidney tissue in one patient with renal tumor and kidney tissue obtained via renal biopsy in one patient with acute tubular necrosis, respectively, including the H&E staining showing the renal tubular injury, the IHC and IF staining to detect the expression of ALOX5, and the representative EM images of morphological changes in mitochondria cristae shape associated with ferroptosis (red arrow head) in renal tubular cells. Abbreviations: ATN acute tubular necrosis, IF immunofluorescence, IHC immunohistochemistry, EM electron microscopy, LM light microscopy.

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