Fig. 2: Single-cell RNA sequencing of LN mice kidneys identified 11 distinct cell subgroups. | Communications Biology

Fig. 2: Single-cell RNA sequencing of LN mice kidneys identified 11 distinct cell subgroups.

From: Cxcl9high macrophages recruit circulating Cxcr3+ plasmablasts into kidneys to promote pathogenesis of lupus nephritis mice

Fig. 2

A Experimental flowchart. B UMAP plot illustrating cell clusters derived from combined single-cell data (87,906 cells) from the kidneys of three groups of LN mice, with each dot representing an individual cell and each color indicating a distinct cell subgroup. C Violin plot displaying the expression levels of typical marker genes for each cell subgroups. D Heatmap depicting the expression levels of the top 10 DEGs across each cell subgroups. E UMAP illustrating the distribution of cell clusters by sample grouping after integrating the single-cell data from the kidneys of the three groups of LN mice. F Circular plots showing the distribution ratio of each cell subgroups in the kidneys of the three groups for LN mice.

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