Fig. 4: Functional enrichment of B and plasma cell subtypes in the kidneys of LN mice. | Communications Biology

Fig. 4: Functional enrichment of B and plasma cell subtypes in the kidneys of LN mice.

From: Cxcl9high macrophages recruit circulating Cxcr3+ plasmablasts into kidneys to promote pathogenesis of lupus nephritis mice

Fig. 4

A The top 5 highly expressed genes in Naive B cells, MBC (memory B cells), Trans PC1, Trans PC2, Trans PC3, Trans PC4, PC1, and PC2. B Heatmap showing KEGG enriched pathways of 8 cell subtypes. C Heatmap showing GO enriched pathways of 8 cell subtypes. Heatmap was performed using the OmicStudio tools at https://www.omicstudio.cn. D–K Dot plots showed significant differences in enrichment of the main enriched pathways among three groups of the eight types of cells. KEGG/GO legend = Log10 (Q.value), legend_max = 0 legend_min = −6, log_tip = 1e-6; Size: Rich.Factor; Color: Log10 (Q.value)/20. PB (plasmablasts), SLPCs (Short-lived plasma cells), LLPCs (Long-lived plasma cells). G Enzyme-linked immunosorbent spot (ELISPOT) assay was used to detect the number of IgG-secreting cells in the kidneys of LN mice. Data are presented as mean ± SD. (n = 6), *p < 0.05, **p < 0.01, ***p < 0.001.

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