Fig. 9: Synthetic applications and conformational analysis.

a Gram scale synthesis of 49. b X-ray single-crystal diffraction analysis of 5 and 8. cThe conformation of 5. d Variable-temperature 1H NMR of 5.

a Gram scale synthesis of 49. b X-ray single-crystal diffraction analysis of 5 and 8. cThe conformation of 5. d Variable-temperature 1H NMR of 5.