Fig. 1: The basic process of ABMP approach and activity-based probes of AGALs. | Communications Chemistry

Fig. 1: The basic process of ABMP approach and activity-based probes of AGALs.

From: Activity-based metaproteomics driven discovery and enzymological characterization of potential α-galactosidases in the mouse gut microbiome

Fig. 1

a Workflow of the ABMP approach for high-throughput screening of gut microbiome samples. b The AGAL activity-based probe (ABP1 and ABP2) structure with a cyclophellitol-aziridine scaffold for selective labeling of active AGALs. c Mechanism-based inhibition of active AGALs by cyclophellitol-derived ABPs.

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