Fig. 1: Unifying scheme describing the diversity of the GPA BGCs found in Pseudonocardiales spp. | Communications Chemistry

Fig. 1: Unifying scheme describing the diversity of the GPA BGCs found in Pseudonocardiales spp.

From: A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650

Fig. 1

On the left side, the MLP of the 33 GPA BGCs selected from the genomic records of Pseudonocardiales spp. (see Supplementary Table 1) is represented: concatenated protein sequences of central biosynthetic enzymes encoded in each BGC (see main text) were used to build the unrooted maximum-likelihood phylogenetic tree (bootstrap values of branch support analysis were obtained from 500 replicates). The names of the GPAs are reported under the species previously known to produce them. To the right, the predicted domain architecture of each NRPS (where the non-ribosomal codes are given) is reported, as well as the schematic representation of monooxygenases and of the other tailoring enzymes taking part in post NRPS biosynthetic steps, coded within the corresponding BGCs (see Supplementary Table 2).

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