Table 1 Minimum inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of Kmc in comparison to the clinically-approved first-generation GPAs vancomycin and teicoplanin

From: A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650

Strain

Kineomicin

Vancomycin

Teicoplanin

MIC (µg mL−1)

MBC (µg mL−1)

MIC (µg mL−1)

MBC (µg mL−1)

MIC (µg mL−1)

MBC (µg mL−1)

Staphylococcus aureus ATCC 6538 P (MSSA)

2

4

1

4

0.5

4

Staphylococcus aureus ATCC 25923 (MSSA)

0.5

2

0.5

2

0.5

2

Staphylococcus aureus ATCC 43300 (MRSA)

2

8

2

8

1

16

Staphylococcus haemolyticus 3902

8

>128

2

16

32

64

Staphylococcus epidermidis strain 4

2

64

4

16

4

64

Enterococcus faecalis ATCC 29212

4

8

2

32

1

64

Enterococcus faecalis ATCC 51299 (VanB)

16

>128

8

>128

2

32

Enterococcus faecalis 9160188401-EF-34 (VanA)

>128

>128

128

>128

32

>128

Escherichia coli ATCC 35218

>128

>128

>128

>128

>128

>128

Moraxella catarrhalis ATCC 3293

>128

>128

>128

>128

>128

>128

  1. Values represent the average of the data from at least three independent experiments. According to the Clinical and Laboratory Standards Institute, strains can be classified as susceptible (MIC ≤ 2 µg mL−1), intermediate resistant (4 ≤ MIC ≤ 8 µg mL−1), or resistant (MIC ≥ 16 µg mL−1)83.
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