Fig. 2: The interfaces targeted by compounds and chemical structures of the compounds. | Communications Chemistry

Fig. 2: The interfaces targeted by compounds and chemical structures of the compounds.

From: A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor

Fig. 2

A All atom structure of basal arrestin-3 highlighting the two interface regions targeted by drug discovery: the back loop characterized by the short helix (red box) and the gate loop (blue box). B Structures of the candidate compounds selected after virtual screening and close-up of complexes: from left to right, LSH-1, LSH-2, LSH-3, LGL.

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