Fig. 9: Toxin neutralisation through receptor mimicry. | Communications Chemistry

Fig. 9: Toxin neutralisation through receptor mimicry.

From: Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen

Fig. 9

Overlay of the TPL1158_01_C09 with α-cobratoxin crystal structure (this study) with the nAChRα1-subunit in complex with α-bungarotoxin (PDB accession code: 2QC1), highlighting the similar binding modes. The toxin structures are coloured in purple; the structure of TPL1158_01_C09 with α-cobratoxin (this study) is shown in cyan, and the nAChRα1-subunit is depicted in grey. A close-up of three aromatic residues in the nAChR α1-loop C (F189, Y190, and Y198), along with similar structural features in the VHH’s CDR3 loop (Y100, Y102, and W99) mimicking the structural features of the acetylcholine receptor.

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