Fig. 8: Binding modes of lipid a moiety of E. coli LPS, A. baumannii Lipid A (2), and Lipid IV_A (6).

A Inverted binding mode of lipid A moiety of E. coli LPS in TLR4/MD-2 complex. B. Inverted binding mode of A. baumannii acyl₆ lipid A (2) in TLR4/MD-2 complex. C. Retained binding mode of IV_A (6) in MD-2 receptor.