Fig. 6: Establishing the biosynthetic route of mangromycin C (21) by de novo engineering in Streptomyces cinnamoneus.
From: Gene conversion-associated successive engineering of modular polyketide synthases
Proposed biosynthetic route of mangromycin C generated using S. cinnamoneus as a template. The gray triangle labeled B represents the in-frame deletion of cmmB gene in S5-mgmKS5 strain. The arrows labeled in A and C1 represent the open reading frames of cmmA and cmmC1.
