Fig. 2: Generation and comparison of databases.

a Rules for the construction of databases. Molecules in Database A were generated by systematically combining donor (D), bridge (B), and acceptor (A) fragments at predetermined positions. Databases B, C, and D were created with an in-house molecular generator. b Chemical space representation of each database, derived from the UMAP dimensionality reduction on Morgan fingerprint. c Molecular-weight distributions across each database.