Fig. 3: Structural elucidation of + 32 Da peroxide species. | Communications Chemistry

Fig. 3: Structural elucidation of + 32 Da peroxide species.

From: Spotlighting the criticality of lipid quality control through a mechanistic investigation of mRNA activity loss in lipid nanoparticles

Fig. 3

a MS2 fragmentation analysis of the sodium adduct of the +32 Da species (X Da) shows a characteristic 140 Da fragment of a C9 peroxide species and b an 88 Da fragment of a C13 peroxide species. c IL has tails containing unsaturated dialkene groups that are susceptible to peroxidation at the C9 or C13 position. Dialkene tails convert to form reactive aldehyde species along with various other oxidation byproducts.

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