Extended Data Fig. 1: Increased DNA damage in mtDNA mutator mouse embryonic fibroblasts. | Nature Metabolism

Extended Data Fig. 1: Increased DNA damage in mtDNA mutator mouse embryonic fibroblasts.

From: Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Extended Data Fig. 1

Mean fluorescence intensity (MFI) of γH2AX staining per cell; quantification of FACS signals and representative histograms. WT n = 4, Mut n = 4, three independent experiments, P = 0.0287. WT, black dots; mutator, red squares. Data represented as mean ± s.e.m. and analysed with unpaired t-test. n corresponds to biological replicates.

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