Extended Data Fig. 3: APP overexpression leads to adipocyte hypertrophy by impairing stimulated lipolysis (related to Fig. 4a,e–j). | Nature Metabolism

Extended Data Fig. 3: APP overexpression leads to adipocyte hypertrophy by impairing stimulated lipolysis (related to Fig. 4a,e–j).

From: Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

Extended Data Fig. 3

a, Representative images for H&E staining in sWAT sections from control mice (APP-) at different time points following induction with Dox (600 mg per kg (diet weight)), chosen from two independent experiments; scale bars, 161 μm. b, Representative H&E staining images in eWAT sections from APP transgenic mice (APP+) at different time points following induction with Dox (600 mg per kg (diet weight)), chosen from two independent experiments; scale bars, 100 μm. c–e, Lipogenesis-related gene transcriptions in sWAT of APP transgenic mice at different time points of Dox 600 feeding (600 mg per kg (diet weight)): Dgat2 (c), Fasn (d), Scd1 (e) and Srebp1 (f); n = 3 mice per time point. Data are shown as mean ± s.e.m. of biologically independent samples. One-way ANOVA followed by a Tukey post-test (c–f) and no statistical significance was found.

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