Extended Data Fig. 1: APP is increased in WAT in obesity and adipocyte-specific APP overexpressing mice are more sensitive to diet induced obesity (related to Fig. 1a,h). | Nature Metabolism

Extended Data Fig. 1: APP is increased in WAT in obesity and adipocyte-specific APP overexpressing mice are more sensitive to diet induced obesity (related to Fig. 1a,h).

From: Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

Extended Data Fig. 1

a–f, The correlation between APP mRNA levels in sWAT from people with obesity with body mass (a), BMI (b), subcutaneous AT volume (c), triglycerides (d), fasting insulin (e) and HDL-cholesterol (f) levels. n = 23 (a–d) or 24 (e,f) subjects. g, App transcription in the brain in acute HFD-challenged wild-type mice for 0, 1, 2, 5, 7 and 14 d. n = 7 for Day 0 group; n = 5 for Day 1, 2, 5, 7 and 14 groups. Data are shown as mean ± s.e.m. of biologically independent samples. Pearson correlation analysis for correlation coefficient (r) and two-tailed P value (a–f); one-way ANOVA followed by a Tukey post-test, and non-significance was found (g).

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