Extended Data Fig. 7: Weight and organ morphology of mice treated with Phenazine methosulphate (PMS) or normal saline (NS) and the effect of combination of PMS and 5-FU or CDDP.
From: Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine
a. Weight of mice transplanted with EV or SRR-KO cells of DLD-1 and treated with PMS or normal saline (NS). Data are presented as mean ± SD of n = 6 mice per group. b. Hematoxylin and eosin (HE) stains of liver, kidney, lung and myocardium of mice transplanted with EV or SRR-KO cells of DLD-1 and treated with PMS or NS. Scale bars, 500 μm in figures of liver, lung and myocardium, and 200 µm in figures of kidney. Images are representative of six mice per group c. Number of cells of EV and SRR-KO DLD-1 and HCT116 cells after incubation with vehicle (DDW), phenazine methosulphate (PMS), 5-fluorouracil (5-FU) or cisplatin (CDDP), and PMS with 5-FU or CDDP for 5 days. Data are ratios relative to number of cells treated with vehicle, and are means ± SD of n = 3 biologically independent samples and are representative of two independent experiments. P-values were determined by two-tailed Student’s t-test.
