Extended Data Fig. 6: The effect of dapagliflozin on insulin-induced changes in intracellular Na+.
From: Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells
a, The effects of dapagliflozin (1 µM) on the insulin-dependent potentiation of αMDG-induced increase in [Na+]i. All experiments measured in 1 mM glucose in the presence of 19 mM αMDG. Solid line represents representative insulin-responsive δ-cell. The dashed line represents an insulin-nonresponsive δ-cell. Data in b are mean values ± S.E.M. in of 88 dispersed delta cells from 2 mice. Similar results were seen for a lower concentration of dapagliflozin (1 nM, see Fig. 3e,f). 1-way RM ANOVA with Tukey’s adjustment; *p<0.05 vs. no insulin or dapagliflozin, #p<0.05 vs. 100 nM insulin. All data are represented as mean ± SEM.
